Mortality rates were significantly greater for men than women and relative differences in mortality in patients with a spine fracture versus controls was greatest in younger patients (aged 65–69 years) and declined as age at time of fracture increased. Specifically, Medicare patients over 65 years of age with a spine fracture have been shown to have approximately two times the overall mortality of matched controls, with survival rates consistently significantly lower at 3, 5, and 7 years post-fracture.
Fractures at other skeletal sites, including the spine and wrist, are also associated with substantial disability and functional decline. Hip fractures tend to be the most costly and debilitating of fractures, with approximately 10 to 20% mortality in the year following a hip fracture and more than half of patients unable to return to independent living post-fracture. The burden of osteoporotic fractures is significant, including functional decline, loss of independence, substantial economic impact, and increased morbidity and mortality.
Osteoporosis is an asymptomatic disease characterized by low bone density, poor bone quality, and reduced bone strength and is associated with high risk of fracture.
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